Population pharmacokinetics of cefazolin in critically ill children infected with methicillin-sensitive Staphylococcus aureus

ObjectivesCefazolin is one of curative treatments for infections due to methicillin-sensitive Staphylococcus aureus (MSSA). Both growth and critical illness may impact the pharmacokinetic (PK) parameters. We aimed build a population PK model cefazolin in critically ill children order optimize individual dosing regimens.MethodsWe included all (age < 18 years, body weight (BW) > 2.5 kg) receiving MSSA infection. Cefazolin total plasma concentrations were quantified by high-performance liquid chromatography. A data modelling process was performed with software MONOLIX. Monte Carlo simulations used attain target 100% fT 4 × MIC.ResultsThirty-nine patients median (range) age 7 (0.1–17) years BW 21 (2.8–79) kg included. The ascribed one-compartment model, where typical clearance volume distribution estimations 1.4 L/h 3.3 L respectively. BW, according allometric rules, estimated glomerular filtration rate (eGFR) on two influential covariates. Continuous infusion 100 mg/kg/day increase 150 10 or eGFR >200 mL/min/1.73m2 best schemes reach MIC.ConclusionsIn infected MSSA, continuous seems be most appropriate scheme % MIC normal augmented renal function.